Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss).

ABSTRACT: Dendritic cells are specialized antigen presenting cells that bridge innate and adaptive immunity in mammals. This link between the ancient innate immune system and the more evolutionarily recent adaptive immune system is of particular interest in fish, the oldest vertebrates to have both innate and adaptive immunity. It is unknown whether dendritic cells co-evolved with the adaptive response, or if the connection between innate and adaptive immunity relied on a fundamentally different cell type early in evolution. We approached this question using the teleost model organism, rainbow trout (Oncorhynchus mykiss), with the aim of identifying dendritic cells based on their ability to stimulate naïve T cells. Adapting mammalian protocols for the generation of dendritic cells, we established a

SUBMITTER: Bassity E 

PROVIDER: S-EPMC3299753 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature