Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles.

ABSTRACT: A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

SUBMITTER: Gunawan S 

PROVIDER: S-EPMC3299871 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature