Enhancing diagnosis, prognosis, and therapeutic outcome prediction of gliomas using genomics.

ABSTRACT: Malignant gliomas are the most frequent type of primary brain tumors. Patients' outcome has not improved despite new therapeutics, thus underscoring the need for a better understanding of their genetics and a fresh approach to treatment. The lack of reproducibility in the classification of many gliomas presents an opportunity where genomics may be paramount for accurate diagnosis and therefore best for therapeutic decisions. The aim of this work is to identify large and focal copy number abnormalities (CNA) and loss of heterozygosity (LOH) events in a malignant glioma population. We hypothesized that these explorations will allow discovery of genetic markers that may improve diagnosis and predict outcome. DNA from glioma specimens were subjected to CNA and LOH analyses. Our studies reveale

SUBMITTER: Assem M 

PROVIDER: S-EPMC3300066 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature