Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers.

ABSTRACT:

Background

Metalworking fluids (MWF)--straight, soluble, and synthetic--have overlapping components. We derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence.

Methods

An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k = 0-1.

Results

For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k = 0). Protectiv

SUBMITTER: Friesen MC 

PROVIDER: S-EPMC3301446 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature