Dioxane dibromide mediated bromination of substituted coumarins under solvent-free conditions.

ABSTRACT: An efficient solvent-free protocol for regioselective bromination of substituted coumarins has been developed by using dioxane dibromide as the solid brominating agent. The efficacy of the solvent-free protocol has been established. The effects of the electronic nature and location of the substituents on the outcome of the reaction have been rationalized with a proposed mechanism.

SUBMITTER: Chaudhuri SK 

PROVIDER: S-EPMC3302096 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature