Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice.

ABSTRACT:

Objective

Recent genome-wide association studies have identified a strong association between obesity and common variants in the fat mass and obesity associated (FTO) gene. FTO has been detected in the hypothalamus, but little is known about its regulation in that particular brain structure. The present study addressed the hypothesis that hypothalamic FTO expression is regulated by nutrients, specifically by glucose, and that its regulation by nutrients is impaired in obesity.

Research design and methods

The effect of intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) administration of glucose on hypothalamic Fto mRNA levels was examined in fasted mice. Additionally, the effect of glucose on Fto mRNA levels was also investigated ex vivo using mouse hypothalamic expla

SUBMITTER: Poritsanos NJ 

PROVIDER: S-EPMC3302139 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature