Vif proteins of human and simian immunodeficiency viruses require cellular CBF? to degrade APOBEC3 restriction factors.
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ABSTRACT:
SUBMITTER: Hultquist JF
PROVIDER: S-EPMC3302251 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors.
Hultquist Judd F JF Binka Mawuena M LaRue Rebecca S RS Simon Viviana V Harris Reuben S RS
Journal of virology 20111228 5
HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBFβ allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins from multiple HIV-1 subtypes and is required for the degradation of all human and rhesus Vif-sensitive APOBEC3 proteins by the ...[more]
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