Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs.

ABSTRACT:

Background

Leukotrienes are proinflammatory molecules derived from dietary PUFAs and have been associated with cardiovascular disease (CVD). We previously reported that an A→G variant (rs12746200) of the cytosolic phospholipase A2 group IVA gene (PLA2G4A), which encodes the enzyme that liberates PUFAs from cellular membranes for leukotriene synthesis, decreases the risk of CVD.

Objective

We sought to replicate these initial observations with a more clinically relevant phenotype, such as myocardial infarction (MI), and to determine whether dietary PUFAs mediate this association.

Design

In a Costa Rican case-control data set (n = 3971), rs12746200 was genotyped and was tested for an association with MI. Functional experiments were carried out to determine whether rs1274

SUBMITTER: Hartiala J 

PROVIDER: S-EPMC3302367 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature