A highly conserved residue in the C-terminal helix of HIV-1 matrix is required for envelope incorporation into virus particles.

ABSTRACT: The incorporation of viral envelope (Env) glycoproteins into nascent particles is an essential step in the production of infectious human immunodeficiency virus type 1 (HIV-1). This process has been shown to require interactions between Env and the matrix (MA) domain of the Gag polyprotein. Previous studies indicate that several residues in the N-terminal region of MA are required for Env incorporation. However, the precise mechanism by which Env proteins are acquired during virus assembly has yet to be fully defined. Here, we examine whether a highly conserved glutamate at position 99 in the C-terminal helix is required for MA function and HIV-1 replication. We analyze a panel of mutant viruses that contain different amino acid substitutions at this position using viral infectivity studie

SUBMITTER: Brandano L 

PROVIDER: S-EPMC3302379 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature