Local response to microneedle-based influenza immunization in the skin.

ABSTRACT:

Unlabelled

Microneedle patches (MN) provide a novel method of vaccine delivery to the skin with the objective of targeting the large network of resident antigen-presenting cells to induce an efficient immune response. Our previous reports demonstrated that cutaneous delivery of inactivated influenza virus-coated MN to mice protects against lethal infection. Protection is correlated with sustained levels of anti-influenza virus serum antibodies, hemagglutination inhibition titers, and robust cellular responses that are often stronger than those generated by intramuscular vaccination. Here we dissect the early events occurring in murine skin after microneedle delivery of inactivated influenza virus. We demonstrate correlation of immunization against influenza virus with a local incre

SUBMITTER: del Pilar Martin M 

PROVIDER: S-EPMC3302568 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature