Increased furan tolerance in Escherichia coli due to a cryptic ucpA gene.

ABSTRACT: Expression arrays were used to identify 4 putative oxidoreductases that were upregulated (>3-fold) by furfural (15 mM, 15 min). Plasmid expression of one (ucpA) increased furan tolerance in ethanologenic strain LY180 and wild-type strain W. Deleting ucpA decreased furfural tolerance. Although the mechanism remains unknown, the cryptic ucpA gene is now associated with a phenotype: furan resistance.

SUBMITTER: Wang X 

PROVIDER: S-EPMC3302629 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature