Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease.

ABSTRACT:

Background and objectives

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by increased total kidney volume (TKV) and renal failure. This study aimed to determine if height-adjusted TKV (htTKV) predicts the onset of renal insufficiency.

Design, setting, participants, & measurements

This prospective, observational, longitudinal, multicenter study included 241 adults with ADPKD and preserved renal function. Magnetic resonance imaging and iothalamate clearance were used to measure htTKV and GFR, respectively. The association between baseline htTKV and the attainment of stage 3 CKD (GFR <60 ml/min per 1.73 m(2)) during follow-up was determined.

Results

After a mean follow-up of 7.9 years, stage 3 CKD was attained in 30.7% of the enrollees. Using basel

SUBMITTER: Chapman AB 

PROVIDER: S-EPMC3302672 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature