MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects.

ABSTRACT:

Background

Recent studies suggest that alterations in expression of genes, including those which regulate neural and structural plasticity, may be crucial in the pathogenesis of depression. MicroRNAs (miRNAs) are newly discovered regulators of gene expression that have recently been implicated in a variety of human diseases, including neuropsychiatric diseases.

Methodology/principal findings

The present study was undertaken to examine whether the miRNA network is altered in the brain of depressed suicide subjects. Expression of miRNAs was measured in prefrontal cortex (Brodmann Area 9) of antidepressant-free depressed suicide (n = 18) and well-matched non-psychiatric control subjects (n = 17) using multiplex RT-PCR plates. We found that overall miRNA expression was significa

SUBMITTER: Smalheiser NR 

PROVIDER: S-EPMC3302855 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature