The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial.

ABSTRACT:

Objectives

Nosocomial infection/sepsis occurs in up to 40% of children requiring long-term intensive care. Zinc, selenium, glutamine, metoclopramide (a prolactin secretalogue), and/or whey protein supplementation have been effective in reducing infection and sepsis in other populations. We evaluated whether daily nutriceutical supplementation with zinc, selenium, glutamine, and metoclopramide, compared to whey protein, would reduce the occurrence of nosocomial infection/sepsis in this at-risk population.

Design

Randomized, double-blinded, comparative effectiveness trial.

Setting

Eight pediatric intensive care units in the National Institutes of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

Patients

Two hundred ninety

SUBMITTER: Carcillo JA 

PROVIDER: S-EPMC3302948 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature