Comparative safety of antipsychotic medications in nursing home residents.

ABSTRACT:

Objectives

To compare the risk of major medical events in nursing home residents newly initiated on conventional or atypical antipsychotic medications (APMs).

Design

Cohort study, using linked Medicaid, Medicare, Minimum Data Set, and Online Survey Certification and Reporting data. Propensity score-adjusted proportional hazards models were used to compare risks for medical events at a class and individual drug level.

Setting

Nursing homes in 45 U.S. states.

Participants

Eighty-three thousand nine hundred fifty-nine Medicaid-eligible residents aged 65 and older who initiated APM treatment after nursing home admission in 2001 to 2005.

Measurements

Hospitalization for myocardial infarction, cerebrovascular events, serious bacterial infections, and hip fract

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC3302976 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature