A scoring system for the assessment of clinical severity in osteogenesis imperfecta.

ABSTRACT:

Introduction

Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility and fractures. Patients with OI have clinical features that may range from mild symptoms to severe bone deformities and neonatal lethality. Numerous approaches for the classification of OI have been published. The Sillence classification is the most commonly used. In this study, we aimed at developing a more refined sub-classification by applying a proposed scoring system for the quantitative assessment of clinical severity in different types of OI.

Subjects and methods

This study included 43 patients with OI. Clinical examination and radiological studies were conducted for all patients. Cases were classified according to the Sillence classification into types I-IV. The proposed s

SUBMITTER: Aglan MS 

PROVIDER: S-EPMC3303020 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature