Anterior cingulate proton spectroscopy glutamate levels differ as a function of smoking cessation outcome.

ABSTRACT:

Background

Cigarette smoking is the leading preventable cause of death. Unfortunately, the majority of smokers who attempt to quit smoking relapse within weeks. Abnormal dorsal anterior cingulate cortex (dACC) function may contribute to tobacco smoking relapse vulnerability. Growing evidence suggests that glutamate neurotransmission is involved in mediating nicotine dependence. We hypothesized that prior to a cessation attempt, dACC glutamate levels would be lower in relapse vulnerable smokers.

Methods

Proton magnetic resonance spectra (MRS) were obtained from dACC and a control region, the parieto-occipital cortex (POC), using two-dimensional J-resolved MRS at 4T and analyzed using LCModel. Nine nicotine-dependent women were scanned prior to making a quit attempt. Subjects

SUBMITTER: Mashhoon Y 

PROVIDER: S-EPMC3303218 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature