Identification of gene-oriented exon orthology between human and mouse.

ABSTRACT:

Background

Gene orthology has been well studied in the evolutionary area and is thought to be an important implication to functional genome annotations. As the accumulation of transcriptomic data, alternative splicing is taken into account in the assignments of gene orthologs and the orthology is suggested to be further considered at transcript level. Whether gene or transcript orthology, exons are the basic units that represent the whole gene structure; however, there is no any reported study on how to build exon level orthology in a whole genome scale. Therefore, it is essential to establish a gene-oriented exon orthology dataset.

Results

Using a customized pipeline, we first build exon orthologous relationships from assigned gene orthologs pairs in two well-annotated geno

SUBMITTER: Fu GC 

PROVIDER: S-EPMC3303729 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature