A study on promoter characteristics of head-to-head genes in Saccharomyces cerevisiae.

ABSTRACT:

Background

Head-to-head (h2h) genes are prone to have association in expression and in functionality and have been shown conserved in evolution. Currently there are many studies on such h2h gene pairs. We found that the previous studies extremely focused on human genome. Furthermore, they only focused on analyses that require only gene or protein sequences but not conducted a systematic investigation on other promoter features such as the binding evidence of specific transcription factors (TFs). This is mainly because of the incomplete resources of higher organisms, though they are relatively of interest, than model organisms such as Saccharomyces cerevisiae. The authors of this study recently integrated nine promoter features of 6603 genes of S. cerevisiae from six databases and f

SUBMITTER: Chang DT 

PROVIDER: S-EPMC3303733 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature