DNA methylation patterns in cord blood DNA and body size in childhood.

ABSTRACT:

Background

Epigenetic markings acquired in early life may have phenotypic consequences later in development through their role in transcriptional regulation with relevance to the developmental origins of diseases including obesity. The goal of this study was to investigate whether DNA methylation levels at birth are associated with body size later in childhood.

Principal findings

A study design involving two birth cohorts was used to conduct transcription profiling followed by DNA methylation analysis in peripheral blood. Gene expression analysis was undertaken in 24 individuals whose biological samples and clinical data were collected at a mean ± standard deviation (SD) age of 12.35 (0.95) years, the upper and lower tertiles of body mass index (BMI) were compared with a mea

SUBMITTER: Relton CL 

PROVIDER: S-EPMC3303769 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature