Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2.

ABSTRACT: Cross-reactive dengue virus (DENV) antibodies directed against the envelope (E) and precursor membrane (prM) proteins are believed to contribute to the development of severe dengue disease by facilitating antibody-dependent enhancement of infection. We and others recently demonstrated that anti-prM antibodies render essentially non-infectious immature DENV infectious in Fcγ-receptor-expressing cells. Immature DENV particles are abundantly present in standard (st) virus preparations due to inefficient processing of prM to M during virus maturation. Structural analysis has revealed that the E protein is exposed in immature particles and this prompted us to investigate whether antibodies to E render immature particles infectious. To this end, we analyzed the enhancing properties of 27 anti-E

SUBMITTER: da Silva Voorham JM 

PROVIDER: S-EPMC3303773 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature