UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria.

ABSTRACT:

Background

Targeting conserved proteins of bacteria through antibacterial medications has resulted in both the development of resistant strains and changes to human health by destroying beneficial microbes which eventually become breeding grounds for the evolution of resistances. Despite the availability of more than 800 genomes sequences, 430 pathways, 4743 enzymes, 9257 metabolic reactions and protein (three-dimensional) 3D structures in bacteria, no pathogen-specific computational drug target identification tool has been developed.

Methods

A web server, UniDrug-Target, which combines bacterial biological information and computational methods to stringently identify pathogen-specific proteins as drug targets, has been designed. Besides predicting pathogen-specific proteins

SUBMITTER: Chanumolu SK 

PROVIDER: S-EPMC3303792 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature