A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma.

ABSTRACT: Epithelial Mesenchymal Transition (EMT) is a crucial mechanism for carcinoma progression, as it provides routes for in situ carcinoma cells to dissociate and become motile, leading to localized invasion and metastatic spread. Targeting EMT therefore represents an important therapeutic strategy for cancer treatment. The discovery of oncogene addiction in sustaining tumor growth has led to the rapid development of targeted therapeutics. Whilst initially optimized as anti-proliferative agents, it is likely that some of these compounds may inhibit EMT initiation or sustenance, since EMT is also modulated by similar signaling pathways that these compounds were designed to target. We have developed a novel screening assay that can lead to the identification of compounds that can inhibit EMT init

SUBMITTER: Chua KN 

PROVIDER: S-EPMC3303807 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature