Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer.

ABSTRACT:

Background

To investigate the potential of serum miRNAs as biomarkers for early detection of gastric cancer (GC), a population-based study was conducted in Linqu, a high-risk area of GC in China.

Methodology/principal findings

All subjects were selected from two large cohort studies. Differential miRNAs were identified in serum pools of GC and control using TaqMan low density array, and validated in individual from 82 pairs of GC and control, and 46 pairs of dysplasia and control by real-time quantitative reverse transcription-polymerase chain reaction. The temporal trends of identified serum miRNA expression were further explored in a retrospective study on 58 GC patients who had at least one pre-GC diagnosis serum sample based on the long-term follow-up population. The miR

SUBMITTER: Song MY 

PROVIDER: S-EPMC3303856 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature