Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort.

ABSTRACT:

Background

The natural history of prostate cancer is highly variable and it is difficult to predict. We showed previously that a cell cycle progression (CCP) score was a robust predictor of outcome in a conservatively managed cohort diagnosed by transurethral resection of the prostate. A greater need is to predict outcome in patients diagnosed by needle biopsy.

Methods

Total RNA was extracted from paraffin specimens. A CCP score was calculated from expression levels of 31 genes. Clinical variables consisted of centrally re-reviewed Gleason score, baseline prostate-specific antigen level, age, clinical stage, and extent of disease. The primary endpoint was death from prostate cancer.

Results

In univariate analysis (n=349), the hazard ratio (HR) for death from prostate

SUBMITTER: Cuzick J 

PROVIDER: S-EPMC3304411 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature