No evidence for the involvement of XMRV or MCV in the pathogenesis of breast cancer.

ABSTRACT:

Background

The aetiology of breast cancer remains elusive. A viral aetiology has been proposed, but to date no virus has been conclusively demonstrated to be involved. Recently, two new viruses, namely Merkel cell polyomavirus (MCV) and xenotropic murine leukaemia virus-related virus (XMRV) have been identified and implicated in the pathogenesis of Merkel cell carcinoma (MCC) and familial form of prostate cancer, respectively.

Methods

We examined 204 samples from 58 different cases of breast cancer for presence of MCV or XMRV by PCR. Samples consisted of both malignant and non-malignant tissues. Additionally, we included 6 cases of MCC and 12 cases of prostate cancer as potential controls for MCV and XMRV, respectively.

Results

All of the breast cancer samples examine

SUBMITTER: Khan G 

PROVIDER: S-EPMC3304419 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature