Boronate-mediated biologic delivery.

ABSTRACT: Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.

SUBMITTER: Ellis GA 

PROVIDER: S-EPMC3304437 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature