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Boronate-mediated biologic delivery.

ABSTRACT: Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.

SUBMITTER: Ellis GA

PROVIDER: S-EPMC3304437 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Boronate-mediated biologic delivery.

Ellis Gregory A GA Palte Michael J MJ Raines Ronald T RT

Journal of the American Chemical Society 20120213 8

Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells. ...[more]

PMID: 22303837

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