Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.

ABSTRACT:

Background

Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking.

Methods

To precisely quantify the association of the single nucleotide polymorphism (SNP rs1061170, 'Y402H') with risk of AMD among studies with differing study designs, participant ancestry and AMD grade and to investigate effect modification by smoking, we report two unpublished genetic association studies (n = 2759) combined with data from 24 published studies (26 studies, 26,494 individuals, including 14,174 cases of AMD) of European ancestry

SUBMITTER: Sofat R 

PROVIDER: S-EPMC3304526 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature