An integrated model of electrical spiking, bursting, and calcium oscillations in GnRH neurons.

ABSTRACT: The plasma membrane electrical activities of neurons that secrete gonadotropin-releasing hormone (GnRH) have been studied extensively. A couple of mathematical models have been developed previously to explain different aspects of these activities. The goal of this article is to develop a single model that accounts for the previously modeled experimental results and some more recent results that have not been accounted for. The latter includes two types of membrane potential bursting mechanisms and their associated cytosolic calcium oscillations. One bursting mechanism has not been reported in experiments and is thus regarded as a model prediction. Although the model is mainly based on data collected in immortalized GnRH cell lines, it is capable of explaining some properties of GnRH neuron

SUBMITTER: Fletcher PA 

PROVIDER: S-EPMC3304551 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature