Association of angiotensin-converting enzyme inhibitor-associated angioedema with transplant and immunosuppressant use.

ABSTRACT:

Background

Immunosuppressants decrease circulating dipeptidyl peptidase IV (DPPIV) activity in transplant patients, and decreased DPPIV activity has been associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. One study has reported an increased incidence of ACE inhibitor-associated angioedema among transplant patients compared to published rates, while several case series report angioedema in patients taking specific immunosuppressant agents.

Objective

To test the hypothesis that transplant patients are at increased risk of ACE inhibitor-associated angioedema.

Methods

We assessed the proportion of transplant patients in 145 cases with ACE inhibitor-associated angioedema and 280 ACE inhibitor-exposed controls. We measured the relationship

SUBMITTER: Byrd JB 

PROVIDER: S-EPMC3305268 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature