Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.

ABSTRACT: More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of -27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Meta-analyses on 147 SNPs we

SUBMITTER: Lill CM 

PROVIDER: S-EPMC3305333 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature