Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line.

ABSTRACT:

Background

Because of the structural and molecular similarities between the two systems, the lateral line, a fish and amphibian specific sensory organ, has been widely used in zebrafish as a model to study the development/biology of neuroepithelia of the inner ear. Both organs have hair cells, which are the mechanoreceptor cells, and supporting cells providing other functions to the epithelium. In most vertebrates (excluding mammals), supporting cells comprise a pool of progenitors that replace damaged or dead hair cells. However, the lack of regenerative capacity in mammals is the single leading cause for acquired hearing disorders in humans.

Results

In an effort to understand the regenerative process of hair cells in fish, we characterized and cloned an egfp transgenic sta

SUBMITTER: Behra M 

PROVIDER: S-EPMC3305402 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature