Plasmodium vivax populations revisited: mitochondrial genomes of temperate strains in Asia suggest ancient population expansion.

ABSTRACT:

Background

Plasmodium vivax is the most widely distributed human malaria parasite outside of Africa, and its range extends well into the temperate zones. Previous studies provided evidence for vivax population differentiation, but temperate vivax parasites were not well represented in these analyses. Here we address this deficit by using complete mitochondrial (mt) genome sequences to elucidate the broad genetic diversity and population structure of P. vivax from temperate regions in East and Southeast Asia.

Results

From the complete mtDNA sequences of 99 clinical samples collected in China, Myanmar and Korea, a total of 30 different haplotypes were identified from 26 polymorphic sites. Significant differentiation between different East and Southeast Asian parasite populatio

SUBMITTER: Miao M 

PROVIDER: S-EPMC3305529 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature