A searchable cross-platform gene expression database reveals connections between drug treatments and disease.

ABSTRACT:

Background

Transcriptional data covering multiple platforms and species is collected and processed into a searchable platform independent expression database (SPIED). SPIED consists of over 100,000 expression fold profiles defined independently of control/treatment assignment and mapped to non-redundant gene lists. The database is thus searchable with query profiles defined over genes alone. The motivation behind SPIED is that transcriptional profiles can be quantitatively compared and ranked and thus serve as effective surrogates for comparing the underlying biological states across multiple experiments.

Results

Drug perturbation, cancer and neurodegenerative disease derived transcriptional profiles are shown to be effective descriptors of the underlying biology as they ret

SUBMITTER: Williams G 

PROVIDER: S-EPMC3305579 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature