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Effects of sterol regulatory element-binding protein (SREBP) in chickens.

ABSTRACT: Sterol regulatory element binding protein- 1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty acids. The SREBP have mostly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, though, a paucity of information on birds, in which lipogenesis occurs essentially in the liver as in humans. Since a prelude to the investigation of the role of SREBP in lipid metabolism regulation in chicken, we review Size and Tissue expression Pattern of SREBP and role of this protein in chickens.

SUBMITTER: Khesht FA 

PROVIDER: S-EPMC3305589 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Effects of sterol regulatory element-binding protein (SREBP) in chickens.

Khesht Fahimeh Alipour FA   Hassanabadi Ahmad A  

Lipids in health and disease 20120206

Sterol regulatory element binding protein- 1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty acids. The SREBP have mostly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, though, a paucity of information on birds, in which lipogenesis occurs essentially in the liver as in humans. Since a prelude to the investigation of the role of SREBP in lipid metabolism regulation in chicken, we re  ...[more]

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