Ontology highlight
ABSTRACT:
SUBMITTER: Guo W
PROVIDER: S-EPMC3305806 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Cell 20120301 5
Regulatory networks orchestrated by key transcription factors (TFs) have been proposed to play a central role in the determination of stem cell states. However, the master transcriptional regulators of adult stem cells are poorly understood. We have identified two TFs, Slug and Sox9, that act cooperatively to determine the mammary stem cell (MaSC) state. Inhibition of either Slug or Sox9 blocks MaSC activity in primary mammary epithelial cells. Conversely, transient coexpression of exogenous Slu ...[more]