Rule-based multi-level modeling of cell biological systems.

ABSTRACT:

Background

Proteins, individual cells, and cell populations denote different levels of an organizational hierarchy, each of which with its own dynamics. Multi-level modeling is concerned with describing a system at these different levels and relating their dynamics. Rule-based modeling has increasingly attracted attention due to enabling a concise and compact description of biochemical systems. In addition, it allows different methods for model analysis, since more than one semantics can be defined for the same syntax.

Results

Multi-level modeling implies the hierarchical nesting of model entities and explicit support for downward and upward causation between different levels. Concepts to support multi-level modeling in a rule-based language are identified. To those belong r

SUBMITTER: Maus C 

PROVIDER: S-EPMC3306009 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature