Implication of European-derived adiposity loci in African Americans.

ABSTRACT:

Objective

Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans.

Methods

A total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R) were genotyped in 4992 subjects from six African-American cohorts. These SNPs were tested for association with body mass index (BMI) after adjustment for age, gender, disease status and population structure in each cohort. Meta-analysis was conducted to combine the results.

Results

Meta-analy

SUBMITTER: Hester JM 

PROVIDER: S-EPMC3306054 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature