Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test.

ABSTRACT: Prolonged demands on the attention system can cause a decay in performance over time known as the time-on-task effect. The inter-subject differences in the rate of this decline are large, and recent efforts have been made to understand the biological bases of these individual differences. In this study, we investigate the genetic correlates of the time-on-task effect, as well as its accompanying changes in subjective fatigue and mood. N = 332 subjects performed a 20-minute test of sustained attention (the Psychomotor Vigilance Test) and rated their subjective states before and after the test. We observed substantial time-on-task effects on average, and large inter-individual differences in the rate of these declines. The 10-repeat allele of the variable number of tandem repeats marker (VNT

SUBMITTER: Lim J 

PROVIDER: S-EPMC3306301 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature