Modeling effective dosages in hormetic dose-response studies.

ABSTRACT:

Background

Two hormetic modifications of a monotonically decreasing log-logistic dose-response function are most often used to model stimulatory effects of low dosages of a toxicant in plant biology. As just one of these empirical models is yet properly parameterized to allow inference about quantities of interest, this study contributes the parameterized functions for the second hormetic model and compares the estimates of effective dosages between both models based on 23 hormetic data sets. Based on this, the impact on effective dosage estimations was evaluated, especially in case of a substantially inferior fit by one of the two models.

Methodology/principal findings

The data sets evaluated described the hormetic responses of four different test plant species exposed to 1

SUBMITTER: Belz RG 

PROVIDER: S-EPMC3306408 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature