Endoperoxide synthesis by photocatalytic aerobic [2 + 2 + 2] cycloadditions.

ABSTRACT: Structurally novel endoperoxides can be sythesized by the photocatalytic cyclotrimerization of bis(styrene) substrates with molecular oxygen. The optimal catalyst for this process is Ru(bpz)(3)(2+), which is a markedly more efficient catalyst for these photooxygention reactions than conventional organic photosensitizers. The 1,2-dioxolane products are amenable to synthetic manipulation and can be easily processed to 1,4-diols and γ-hydroxyketones. An initial screen of the biological activity of these compounds reveals promising inhibition of cancer cell growth.

SUBMITTER: Parrish JD 

PROVIDER: S-EPMC3306464 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature