Hypercontrols in genotype-phenotype analysis reveal ancestral haplotypes associated with essential hypertension.

ABSTRACT: The angiotensinogen gene locus has been associated with essential hypertension in most populations analyzed to date. Increased plasma angiotensinogen levels have been proposed as an underlying cause of essential hypertension in whites; however, differences in the genetic regulation of plasma angiotensinogen levels have also been reported for other populations. The aim of this study was to analyze the relationship between angiotensinogen gene polymorphisms and haplotypes with plasma angiotensinogen levels and the risk of essential hypertension in the Mexican population. We genotyped 9 angiotensinogen gene polymorphisms in 706 individuals. Four polymorphisms, A-6, C4072, C6309, and G12775, were associated with increased risk, and the strongest association was found for the C6309 allele (χ(2)

SUBMITTER: Balam-Ortiz E 

PROVIDER: S-EPMC3306465 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature