Enantioselective synthesis of (-)-basiliskamide A.

ABSTRACT: Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available β-hydroxy ester 7. The synthesis features a highly diastereoselective mismatched double asymmetric δ-stannylallylboration reaction of aldehyde 5 with the bifunctional allylborane reagent 4.

SUBMITTER: Chen M 

PROVIDER: S-EPMC3306514 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature