Intramuscular versus intravenous therapy for prehospital status epilepticus.

ABSTRACT:

Background

Early termination of prolonged seizures with intravenous administration of benzodiazepines improves outcomes. For faster and more reliable administration, paramedics increasingly use an intramuscular route.

Methods

This double-blind, randomized, noninferiority trial compared the efficacy of intramuscular midazolam with that of intravenous lorazepam for children and adults in status epilepticus treated by paramedics. Subjects whose convulsions had persisted for more than 5 minutes and who were still convulsing after paramedics arrived were given the study medication by either intramuscular autoinjector or intravenous infusion. The primary outcome was absence of seizures at the time of arrival in the emergency department without the need for rescue therapy. Secondar

SUBMITTER: Silbergleit R 

PROVIDER: S-EPMC3307101 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature