Using biologically interrelated experiments to identify pathway genes in Arabidopsis.

ABSTRACT:

Motivation

Pathway genes are considered as a group of genes that work cooperatively in the same pathway constituting a fundamental functional grouping in a biological process. Identifying pathway genes has been one of the major tasks in understanding biological processes. However, due to the difficulty in characterizing/inferring different types of biological gene relationships, as well as several computational issues arising from dealing with high-dimensional biological data, deducing genes in pathways remain challenging.

Results

In this work, we elucidate higher level gene-gene interactions by evaluating the conditional dependencies between genes, i.e. the relationships between genes after removing the influences of a set of previously known pathway genes. These previously

SUBMITTER: Kim K 

PROVIDER: S-EPMC3307114 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature