Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial.

ABSTRACT:

Objectives

To explore whether a strategy of more intensive antibiotic therapy leads to emergence or prolongation of renal failure in intensive care patients.

Design

Secondary analysis from a randomised antibiotic strategy trial (the Procalcitonin And Survival Study). The randomised arms were conserved from the primary trial for the main analysis.

Setting

Nine mixed surgical/medical intensive care units across Denmark.

Participants

1200 adult intensive care patients, 18+ years, expected to stay +24 h.

Exclusion criteria

bilirubin >40 mg/dl, triglycerides >1000 mg/dl, increased risk from blood sampling, pregnant/breast feeding and psychiatric patients.

Interventions

Patients were randomised to guideline-based therapy ('standard-exposure' arm) or to

SUBMITTER: Jensen JU 

PROVIDER: S-EPMC3307126 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature