Polymorphisms in base-excision & nucleotide-excision repair genes & prostate cancer risk in north Indian population.

ABSTRACT:

Background & objectives

Genetic variation in the DNA repair genes might be associated with altered DNA repair capacities (DRC). Reduced DRC due to inherited polymorphisms may increase the susceptibility to cancers. Base excision and nucleotide excision are the two major repair pathways. We investigated the association between two base excision repair (BER) genes (APE1 exon 5, OGG1 exon 7) and two nucleotide excision repair (NER) genes (XPC PAT, XPC exon 15) with risk of prostate cancer (PCa).

Methods

The study was designed with 192 histopathologically confirmed PCa patients and 224 age matched healthy controls of similar ethnicity. Genotypes were determined by amplification refractory mutation specific (ARMS) and PCR-restriction fragment length polymorphism (RFLP) methods.

SUBMITTER: Mandal RK 

PROVIDER: S-EPMC3307187 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature