The effects of centralised and specialised intervention in the early course of severe unipolar depressive disorder: a randomised clinical trial.

ABSTRACT:

Background

Little is known on whether centralised and specialised combined pharmacological and psychological intervention in the early phase of severe unipolar depression improve prognosis. The aim of the present study was to assess the benefits and harms of centralised and specialised secondary care intervention in the early course of severe unipolar depression.

Methods

A randomised multicentre trial with central randomisation and blinding in relation to the primary outcome comparing a centralised and specialised outpatient intervention program with standard decentralised psychiatric treatment. The interventions were offered at discharge from first, second, or third hospitalisation due to a single depressive episode or recurrent depressive disorder. The primary outcome was

SUBMITTER: Hansen HV 

PROVIDER: S-EPMC3307703 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature