Genetic continuity in the Franco-Cantabrian region: new clues from autochthonous mitogenomes.

ABSTRACT:

Background

The Late Glacial Maximum (LGM), ∼20 thousand years ago (kya), is thought to have forced the people inhabiting vast areas of northern and central Europe to retreat to southern regions characterized by milder climatic conditions. Archaeological records indicate that Franco-Cantabria might have been the major source for the re-peopling of Europe at the beginning of the Holocene (11.5 kya). However, genetic evidence is still scarce and has been the focus of an intense debate.

Methods/principal findings

Based on a survey of more than 345,000 partial control region sequences and the analysis of 53 mitochondrial DNA (mtDNA) genomes, we identified an mtDNA lineage, HV4a1a, which most likely arose in the Franco-Cantabrian area about 5.4 kya and remained confined to norther

SUBMITTER: Gomez-Carballa A 

PROVIDER: S-EPMC3307710 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature