The RhoGEF trio functions in sculpting class specific dendrite morphogenesis in Drosophila sensory neurons.

ABSTRACT:

Background

As the primary sites of synaptic or sensory input in the nervous system, dendrites play an essential role in processing neuronal and sensory information. Moreover, the specification of class specific dendrite arborization is critically important in establishing neural connectivity and the formation of functional networks. Cytoskeletal modulation provides a key mechanism for establishing, as well as reorganizing, dendritic morphology among distinct neuronal subtypes. While previous studies have established differential roles for the small GTPases Rac and Rho in mediating dendrite morphogenesis, little is known regarding the direct regulators of these genes in mediating distinct dendritic architectures.

Methodology/principal findings

Here we demonstrate that the Rho

SUBMITTER: Iyer SC 

PROVIDER: S-EPMC3307743 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature